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Single Molecule Force Spectroscopy on Ligand-Receptor Systems

Robert Ros
Home Department - Physics
Areas of Study - Nanobiophysics
Office - PSB-359
Phone - 4807279280
E-mail - robert.ros@asu.edu
Designation - Experimental

Dynamic force spectroscopy is a well-established tool to study molecular recognition in a wide range of binding affinities on the single-molecule level. In this project an atomic force microscope will be used to study ligand-receptor interactions. Therefore the binding partners have to be immobilized on the AFM-tip and the surface, respectively. In order to obtain force-distance curves the AFM tip is cycled up and down while measuring the force acting on the cantilever. The analysis of the acquired data is still challenging. The data measured in this project will be used in order to improve single molecule data analysis.