Nadia Zatsepin

Research Assistant Professor
Faculty
TEMPE Campus
Mailcode
1504

Biography

Nadia Zatsepin is a Research Assistant Professor in the Center for Biological Physics in the Department of Physics. Her research focuses on the application and development of data analysis tools for time resolved serial femtosecond crystallography, development of serial crystallography at synchrotron and compact X-ray light sources, and novel phasing algorithms for XFEL biological data.

Zatsepin's graduate studies were on X-ray characterization of nanoparticles embedded in light metal alloys, at Monash University (Melbourne, Australia). She joined ASU in 2011 as a postdoc with Professor John C. H. Spence. 

Zatsepin's work is supported by the BioXFEL STC (NSF STC award number 1231306), NSF BIO ABI award #1565180 “ABI Innovations: New Algorithms for biological X-ray free electron laser data”, and NSF MCB award #1817862 "Light-Induced Protein Quake of Visual Rhodopsin Investigated by Femtosecond Time-Resolved X-Ray Scattering".

Education

  • Ph.D. Physics, Monash University, Australia 2011
  • B.Sc. (Hons) Sci Schol Prog., Monash University, Australia 2005

Videos

Google Scholar

Research Interests

serial crystallography, x-ray free electron lasers for biology, phasing

Research Group

Chufeng Li, postdoc

Derek Mendez, postdoc

Natasha Stander, graduate student

Rick Hewitt, undergraduate student

Cameron Howard, undergraduate student

Publications

 

2018

42.  Li, C., Li, X., Kirian, R., Spence, J. C. H., Liu, H. and Zatsepin, N. A. (2018) ‘SPIND: a reference-based auto-indexing algorithm for sparse serial crystallography data’, IUCrJ, pp. 1–28. In            press

41. N. A. Zatsepin, Crystallography with X-ray free electron lasers. In Beis, K. and Evans, G. Protein Crystallography: Challenges and Practical Solutions, Royal Society of Chemistry. 2018. 

40. Ji-Hye Lee, Nadia A Zatsepin, Kyung Hyun Kim. Time-resolved serial femtosecond X-ray crystallography. Bio Design (2018) 6, 25-22.

39. Dan Bi Lee, Jong-Min Kim, Jong Hyeon Seok, Ji-Hye Lee, Jae Deok Jo, Ji Young Mun, Chelsie Conrad, Jesse Coe, Gerrett Nelson, Brenda Hogue, Thomas A White, Nadia Zatsepin, Uwe Weierstall, Anton Barty, Henry Chapman, Petra Fromme, John Spence, Mi Sook Chung, Chang-Hyun Oh, Kyung Hyun Kim. Supersaturation-controlled microcrystallization and visualization analysis for serial femtosecond crystallography. Scientific Reports (2018), 8 (1), 2541 (p1-10).

38. Casadei, C. M., Tsai, C. J., Barty, A., Hunter, M. S., Zatsepin, N. A., Padeste, C., Capitani, G., Benner, W. H., Boutet, S., Hau-Riege, S. P., Kupitz, C., Messerschmidt, M. M., Ogren, J. I., Pardini, T., Rothschild, K. J., Sala, L., Segelke, B., Williams, G. J., Evans, J. E., Li, X. D., Coleman, M., Pedrini, B. and Frank, M. Resolution extension by image summing in serial femtosecond crystallography of two-dimensional membrane-protein crystals, IUCrJ (2018). M5, 103-117

37. Olmos, S. Pandey, J. M. Martin-Garcia, G. Calvey, A. Katz, J. Knoska, C. Kupitz, M. S. Hunter, M. Liang, D. Oberthuer, O. M. Yefanov, M. Wiedorn, M. Heymann, M. Holl, K. Pande, A. Barty, M. D. Miller, S. Stern, S. Roy-Chowdhury, J. D. Coe, N. Nagaratnam, J. D. Zook, T. Norwood, I. Poudyal, D. Xu, J. Koglin, M. Seaberg, Y. Zhao, S. Bajt, T. D. Grant, V. Mariani, G. Nelson, G. Subramanian, E. Bae, R. Fromme, R. Fung, P. Schwander, M. Frank, T. A. White, U. Weierstall, N. A. Zatsepin, J. C. H. Spence, P. T. Fromme, H. N. Chapman, L. Pollack, L. Tremblay, A. Ourmazd, G. N. Phillips Jr, and M. Schmidt, Authentic Enzyme Intermediates Captured ‘on-the-fly’ by Mix-and-Inject Serial Crystallography, BMC Biology, 1-40, May 2018

 

2017

  1. C. Gati, D. Oberthuer, O.M. Yefanov, R.D. Bunker, F. Stellato, E. Chiu, S.-M. Yeh, A. Aquila, S. Basu, R. Bean, K.R. Beyerlein, S. Botha, S. Boutet, D.P. DePonte, R.B. Doak, R. Fromme, L. Galli, I. Grotjohann, D.R. James, C. Kupitz, L. Lomb, M.M. Messerschmidt, K. Nass, K. Rendek, R.L. Shoeman, D. Wang, U. Weierstall, T.A. White, G.J. Williams, N.A. Zatsepin, P.T. Fromme, J.C.H. Spence, K.N. Goldie, J.A. Jehle, P. Metcalf, A. Barty, and H.N. Chapman, Atomic Structure of Granulin Determined From Native Nanocrystalline Granulovirus Using an X-Ray Free-Electron Laser, Proceedings of the National Academy of Sciences 114 (9), 2247–2252, [2017].

  1. C. Kupitz, J.L. Olmos Jr., M. Holl, L. Tremblay, K. Pande, S. Pandey, D. Oberthür, M. Hunter, M. Liang, A. Aquila, J. Tenboer, G. Calvey, A. Katz, Y. Chen, M.O. Wiedorn, J. Knoska, A. Meents, V. Majriani, T. Norwood, I. Poudyal, T.D. Grant, M.D. Miller, W. Xu, A. Tolstikova, A. Morgan, M. Metz, J.M. Martin-Garcia, J.D. Zook, S. Roy-Chowdhury, J. Coe, N. Nagaratnam, D. Meza, R. Fromme, S. Basu, M. Frank, T.A. White, A. Barty, S. Bajt, O.M. Yefanov, H.N. Chapman, N.A. Zatsepin, G. Nelson, U. Weierstall, J.C.H. Spence, P. Schwander, L. Pollack, P.T. Fromme, A. Ourmazd, G.N. Phillips Jr, and M. Schmidt, Structural Enzymology Using X-Ray Free Electron Lasers, Structural Dynamics 4 (4), 044003, [2017].

  1. J.R. Stagno, Y. Liu, Y.R. Bhandari, C.E. Conrad, S. Panja, M. Swain, L. Fan, G. Nelson, C. Li, D.R. Wendel, T.A. White, J.D. Coe, M.O. Wiedorn, J. Knoska, D. Oberthuer, R.A. Tuckey, P. Yu, M. Dyba, S.G. Tarasov, U. Weierstall, T.D. Grant, C.D. Schwieters, J. Zhang, A.R. Ferré-D’Amaré, P. Fromme, D.E. Draper, M. Liang, M.S. Hunter, S. Boutet, K. Tan, X. Zuo, X. Ji, A. Barty, N.A. Zatsepin, H. N. Chapman, J.C.H. Spence, S. A. Woodson & Y.-X. Wang. Structures of riboswitch RNA reaction states by mix-and-inject XFEL serial crystallographyNature 541, 242-246, [2017]. doi:10.1038/nature20599

2016

  1. T. A. White, A. Barty, W. Liu, A. Ishchenko, H. Zhang, C. Gati, N. A. Zatsepin, S. Basu, D. Oberthür, M. Metz, K. R. Beyerlein, C. H. Yoon, O. M. Yefanov, D. James, D. Wang, M. Messerschmidt, J. E. Koglin, S. Boutet, U. Weierstall, and V. Cherezov. Serial femtosecond crystallography datasets from G protein-coupled receptors, Scientific Data, 3 [2016].http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968193/

  1. G. Nelson, R.A. Kirian, U. Weierstall, N.A. Zatsepin, T. Faragó, T. Baumbach, F. Wilde, F.B.P. Niesler, B. Zimmer, I. Ishigami, M. Hikita, S. Bajt, S.-R. Yeh, D.L. Rousseau, H.N. Chapman, J.C.H. Spence, and M. Heymann, Three-Dimensional-Printed Gas Dynamic Virtual Nozzles for X-Ray Laser Sample Delivery, Opt. Express 24 (11), 11515, [2016].

  1. K. Pande, C.D.M. Hutchison, G. Groenhof, A. Aquila, J.S. Robinson, J. Tenboer, S. Basu, S. Boutet, D.P. DePonte, M. Liang, T.A. White, N.A. Zatsepin, O. Yefanov, D. Morozov, D. Oberthuer, C. Gati, G. Subramanian, D. James, Y. Zhao, J. Koralek, J. Brayshaw, C. Kupitz, C. Conrad, S. Roy-Chowdhury, J.D. Coe, M. Metz, P.L. Xavier, T.D. Grant, J.E. Koglin, G. Ketawala, R. Fromme, V. Srajer, R. Henning, J.C.H. Spence, A. Ourmazd, P. Schwander, U. Weierstall, M. Frank, P. Fromme, A. Barty, H.N. Chapman, K. Moffat, J.J. van Thor, and M. Schmidt, Femtosecond Structural Dynamics Drives the Trans/Cis Isomerization in Photoactive Yellow ProteinScience 352 (6286), 725–729, [2016]. http://science.sciencemag.org/content/352/6286/725.full.pdf+html

2015

  1. D. Li, P.J. Stansfeld, M.S.P. Sansom, A. Keogh, L. Vogeley, N. Howe, J.A. Lyons, D. Aragao, P. Fromme, R. Fromme, S. Basu, I. Grotjohann, C. Kupitz, K. Rendek, U. Weierstall, N.A. Zatsepin, V. Cherezov, W. Liu, S. Bandaru, N.J. English, C. Gati, A. Barty, O. Yefanov, H.N. Chapman, K. Diederichs, M. Messerschmidt, S.E.B. Boutet, G.J. Williams, M.M. Seibert, and M. Caffrey, Ternary Structure Reveals Mechanism of a Membrane Diacylglycerol Kinase, Nature Communications 6, 1–12, [2015]. http://www.nature.com/ncomms/2015/151217/ncomms10140/full/ncomms10140.html

  1. B.G. Abdallah, N.A. Zatsepin, S. Roy-Chowdhury, J. Coe, C.E. Conrad, K. Dörner, R.G. Sierra, H.P. Stevenson, F. Camacho-Alanis, T.D. Grant, G. Nelson, D. James, G. Calero, R.M. Wachter, J.C.H. Spence, U. Weierstall, P. Fromme, and A. Ros, Microfluidic Sorting of Protein Nanocrystals by Size for X-Ray Free-Electron Laser Diffraction, Structural Dynamics 2 (4), 041719, [2015]. http://scitation.aip.org/content/aca/journal/sdy/2/4/10.1063/1.4928688

  1. R.M. Lawrence, C.E. Conrad, N.A. Zatsepin, T.D. Grant, H. Liu, D. James, G. Nelson, G. Subramanian, A. Aquila, M.S. Hunter, M. Liang, S. Boutet, J. Coe, J.C.H. Spence, U. Weierstall, W. Liu, P. Fromme, V. Cherezov, and B.G. Hogue, Serial Femtosecond X-Ray Diffraction of Enveloped Virus Microcrystals, Structural Dynamics 2 (4), 041720, [2015]. http://scitation.aip.org/content/aca/journal/sdy/2/4/10.1063/1.4929410

  1. C.E. Conrad, S. Basu, D. James, D. Wang, A. Schaffer, S. Roy-Chowdhury, N.A. Zatsepin, A. Aquila, J. Coe, C. Gati, M.S. Hunter, J.E. Koglin, C. Kupitz, G. Nelson, G. Subramanian, T.A. White, Y. Zhao, J. Zook, S. Boutet, V. Cherezov, J.C.H. Spence, R. Fromme, U. Weierstall, and P. Fromme, A Novel Inert Crystal Delivery Medium for Serial Femtosecond Crystallography, IUCrJ 2, 421–430, [2015]. http://journals.iucr.org/m/issues/2015/04/00/mf5010/mf5010.pdf

  1. Y. Kang, X.E. Zhou, X. Gao, Y. He, W. Liu, A. Ishchenko, A. Barty, T.A. White, O. Yefanov, G.W. Han, Q. Xu, P.W. de Waal, J. Ke, M.H.E. Tan, C. Zhang, A. Moeller, G.M. West, B.D. Pascal, N. van Eps, L.N. Caro, S.A. Vishnivetskiy, R.J. Lee, K.M. Suino-Powell, X. Gu, K. Pal, J. Ma, X. Zhi, S. Boutet, G.J. Williams, M. Messerschmidt, C. Gati, N.A. Zatsepin, D. Wang, D. James, S. Basu, S. Roy-Chowdhury, C.E. Conrad, J. Coe, H. Liu, S. Lisova, C. Kupitz, I. Grotjohann, R. Fromme, Y. Jiang, M. Tan, H. Yang, J. Li, M. Wang, Z. Zheng, D. Li, N. Howe, Y. Zhao, J. Standfuss, K. Diederichs, Y. Dong, C.S. Potter, B. Carragher, M. Caffrey, H. Jiang, H.N. Chapman, J.C.H. Spence, P. Fromme, U. Weierstall, O.P. Ernst, V. Katritch, V.V. Gurevich, P.R. Griffin, W.L. Hubbell, R.C. Stevens, V. Cherezov, K. Melcher, and H.E. Xu, Crystal Structure of Rhodopsin Bound to Arrestin by Femtosecond X-Ray Laser, Nature 523 (7562), 561–567, [2015]. http://www.nature.com/nature/journal/v523/n7562/full/nature14656.html

  1. H. Zhang, H. Unal, C. Gati, G.W. Han, W. Liu, N.A. Zatsepin, D. James, D. Wang, G. Nelson, U. Weierstall, M.R. Sawaya, Q. Xu, M. Messerschmidt, G.J. Williams, S. Boutet, O.M. Yefanov, T.A. White, C. Wang, A. Ishchenko, K.C. Tirupula, R. Desnoyer, J. Coe, C.E. Conrad, P. Fromme, R.C. Stevens, V. Katritch, S.S. Karnik, and V. Cherezov, Structure of the Angiotensin Receptor Revealed by Serial Femtosecond Crystallography, Cell, 161 (4), 833-844, [2015]. http://www.cell.com/cell/abstract/S0092-8674(15)00428-6

  1. A. Soragni, S. Yousefi, C. Stoeckle, A.B. Soriaga, M.R. Sawaya, E. Kozlowski, I. Schmid, S. Radonjic-Hoesli, S. Boutet, G.J. Williams, M. Messerschmidt, M.M. Seibert, D. Cascio, N.A. Zatsepin, M. Burghammer, C. Riekel, J.-P. Colletier, R. Riek, D.S. Eisenberg, and H.-U. Simon, Toxicity of Eosinophil MBP Is Repressed by Intracellular Crystallization and Promoted by Extracellular Aggregation, Molecular Cell 57 (6), 1011–1021, (2015). http://www.cell.com/molecular-cell/abstract/S1097-2765(15)00049-0

  1. G. Fenalti, N.A. Zatsepin, C. Betti, P. Giguere, G.W. Han, A. Ishchenko, W. Liu, K. Guillemyn, H. Zhang, D. James, D. Wang, U. Weierstall, J.C.H. Spence, S. Boutet, M. Messerschmidt, G.J. Williams, C. Gati, O.M. Yefanov, T.A. White, D. Oberthuer, M. Metz, C.H. Yoon, A. Barty, H.N. Chapman, S. Basu, J. Coe, C.E. Conrad, R. Fromme, P. Fromme, D. Tourwé, P.W. Schiller, B.L. Roth, S. Ballet, V. Katritch, R.C. Stevens, and V. Cherezov, Structural Basis for Bifunctional Peptide Recognition at Human δ-Opioid Receptor, Nature Structural & Molecular Biology 22(3), 265–268, (2015). http://www.nature.com/nsmb/journal/v22/n3/full/nsmb.2965.html

  1. P. Nogly, D. James, D. Wang, T.A. White, N.A. Zatsepin, A. Shilova, G. Nelson, H. Liu, L.C. Johansson, M. Heymann, K. Jaeger, M. Metz, C. Wickstrand, W. Wu, P. Bath, P. Bernsten, D. Oberthuer, V. Panneels, V. Cherezov, H.N. Chapman, G. Schertler, R. Neutze, J.C.H. Spence, I. Moraes, M. Burghammer, J. Standfuss, and U. Weierstall, Lipidic Cubic Phase Serial Millisecond Crystallography Using Synchrotron Radiation, IUCrJ, 2, 168-176, (2015). http://journals.iucr.org/m/issues/2015/02/00/jt5008/jt5008.pdf

2014

  1. M. Frank, D.B. Carlson, M.S. Hunter, G.J. Williams, M. Messerschmidt, N.A. Zatsepin, A. Barty, W.H. Benner, K. Chu, A.T. Graf, S.P. Hau-Riege, R.A. Kirian, C. Padeste, T. Pardini, B. Pedrini, B. Segelke, M.M. Seibert, J.C.H. Spence, C.-J. Tsai, S.M. Lane, X.-D. Li, G. Schertler, S. Boutet, M. Coleman, and J.E. Evans, Femtosecond X-Ray Diffraction From Two-Dimensional Protein Crystals, IUCrJ (2014) 1, 95–100, (2014).

  1. H.-H. Lee, I. Cherni, H. Yu, R. Fromme, J.D. Doran, I. Grotjohann, M. Mittman, S. Basu, A. Deb, K. Dörner, A. Aquila, A. Barty, S. Boutet, H.N. Chapman, R.B. Doak, M.S. Hunter, D. James, R.A. Kirian, C. Kupitz, R.M. Lawrence, H. Liu, K. Nass, I. Schlichting, K.E. Schmidt, M.M. Seibert, R.L. Shoeman, J.C.H. Spence, F. Stellato, U. Weierstall, G.J. Williams, C.H. Yoon, D. Wang, N.A. Zatsepin, B.G. Hogue, N. Matoba, P. Fromme, and T.S. Mor, Expression, Purification and Crystallization of CTB-MPR, a Candidate Mucosal Vaccine Component Against HIV-1, IUCrJ (2014) 1, 305–317, (2014).

  1. K.R. Beyerlein, C. Jooss, A. Barty, R. Bean, S. Boutet, S.S. Dhesi, R.B. Doak, M. Först, L. Galli, R.A. Kirian, J. Kozak, M. Lang, R. Mankowsky, M. Messerschmidt, J.C.H. Spence, D. Wang, U. Weierstall, T.A. White, G.J. Williams, O. Yefanov, N.A. Zatsepin, A. Cavalleri, and H.N. Chapman, Trace Phase Detection and Strain Characterization From Serial X-Ray Free-Electron Laser Crystallography of a Pr0.5Ca0.5MnO3 Powder, Powder Diffraction, 1–6, (2014).

  1. M.S. Hunter, B. Segelke, M. Messerschmidt, G.J. Williams, N.A. Zatsepin, A. Barty, W.H. Benner, D.B. Carlson, M. Coleman, A. Graf, S.P. Hau-Riege, T. Pardini, M.M. Seibert, J. Evans, S. Boutet, and M. Frank, Fixed-Target Protein Serial Microcrystallography with an X-Ray Free Electron Laser, Scientific Reports 4, (2014). http://www.nature.com/articles/srep06026

  1. D. Arnlund, L.C. Johansson, C. Wickstrand, A. Barty, G.J. Williams, E. Malmerberg, J. Davidsson, D. Milathianaki, D.P. DePonte, R.L. Shoeman, D. Wang, D. James, G. Katona, S. Westenhoff, T.A. White, A. Aquila, S. Bari, P. Berntsen, M. Bogan, T.B. van Driel, R.B. Doak, K.S. Kjær, M. Frank, R. Fromme, I. Grotjohann, R. Henning, M.S. Hunter, R.A. Kirian, I. Kosheleva, C. Kupitz, M. Liang, A.V. Martin, M.M. Nielsen, M. Messerschmidt, M.M. Seibert, J. Sjöhamn, F. Stellato, U. Weierstall, N.A. Zatsepin, J.C.H. Spence, P. Fromme, I. Schlichting, S. Boutet, G. Groenhof, H.N. Chapman, and R. Neutze, Visualizing a Protein Quake with Time-Resolved X-Ray Scattering at a Free-Electron Laser, Nature Methods 11 (9), 923–926, (2014). http://www.nature.com/nmeth/journal/v11/n9/full/nmeth.3067.html

  1. C. Kupitz, S. Basu, I. Grotjohann, R. Fromme, N.A. Zatsepin, K.N. Rendek, M.S. Hunter, R.L. Shoeman, T.A. White, D. Wang, D. James, J.-H. Yang, D.E. Cobb, B. Reeder, R.G. Sierra, H. Liu, A. Barty, A.L. Aquila, D. Deponte, R.A. Kirian, S. Bari, J.J. Bergkamp, K.R. Beyerlein, M.J. Bogan, C. Caleman, T.-C. Chao, C.E. Conrad, K.M. Davis, H. Fleckenstein, L. Galli, S.P. Hau-Riege, S. Kassemeyer, H. Laksmono, M. Liang, L. Lomb, S. Marchesini, A.V. Martin, M. Messerschmidt, D. Milathianaki, K. Nass, A. Ros, S. Roy-Chowdhury, K. Schmidt, M. Seibert, J. Steinbrener, F. Stellato, L. Yan, C. Yoon, T.A. Moore, A.L. Moore, Y. Pushkar, G.J. Williams, S. Boutet, R.B. Doak, U. Weierstall, M. Frank, H.N. Chapman, J.C.H. Spence, and P. Fromme, Serial Time-Resolved Crystallography of Photosystem II Using a Femtosecond X-Ray Laser, Nature 513 (7517), 261–265, (2014). http://www.nature.com/nature/journal/v513/n7517/full/nature13453.html

  1. J.C.H. Spence, N.A. Zatsepin, and C. Li, Coherent Convergent-Beam Time-Resolved X-Ray Diffraction, Philosophical Transactions of the Royal Society B: Biological Sciences 369 (1647), 20130325–20130325, (2014). http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052862/pdf/rstb20130325.pdf

  1. B. Pedrini, C.-J. Tsai, G. Capitani, C. Padeste, M.S. Hunter, N.A. Zatsepin, A. Barty, W.H. Benner, S. Boutet, G.K. Feld, S.P. Hau-Riege, R.A. Kirian, C. Kupitz, M. Messerschmitt, J.I. Ogren, T. Pardini, B. Segelke, G.J. Williams, J.C.H. Spence, R. Abela, M. Coleman, J.E. Evans, G.F.X. Schertler, M. Frank, and X.-D. Li, 7 Å Resolution in Protein Two-Dimensional-Crystal X-Ray Diffraction at Linac Coherent Light Source, Philosophical Transactions of the Royal Society B: Biological Sciences 369 (1647), 20130500, (2014).http://rstb.royalsocietypublishing.org/content/369/1647/20130500

  1. J. Tenboer, S. Basu, N. Zatsepin, K. Pande, D. Milathianaki, M. Frank, M. Hunter, S. Boutet, G.J. Williams, J.E. Koglin, D. Oberthuer, M. Heymann, C. Kupitz, C. Conrad, J. Coe, S. Roy-Chowdhury, U. Weierstall, D. James, D. Wang, T. Grant, A. Barty, O. Yefanov, J. Scales, Cornelius Gati, C. Seuring, V. Srajer, R. Henning, P. Schwander, R. Fromme, A. Ourmazd, Keith Moffat, J.J. Van Thor, J.C.H. Spence, P. Fromme, Henry N Chapman, and M. Schmidt, Time-Resolved Serial Crystallography Captures High-Resolution Intermediates of Photoactive Yellow ProteinScience 346 (6214), 1242–1246, (2014). http://science.sciencemag.org/content/346/6214/1242

  1. U. Weierstall, D. James, C. Wang, T.A. White, D. Wang, W. Liu, J.C.H. Spence, R.B. Doak, G. Nelson, P. Fromme, R. Fromme, I. Grotjohann, C. Kupitz, N.A. Zatsepin, H. Liu, S. Basu, D. Wacker, G.W. Han, V. Katritch, S.E.B. Boutet, M. Messerschmidt, G.J. Williams, J.E. Koglin, M.M. Seibert, M. Klinker, C. Gati, R.L. Shoeman, A. Barty, H.N. Chapman, R.A. Kirian, K.R. Beyerlein, R.C. Stevens, D. Li, S.T.A. Shah, N. Howe, M. Caffrey, and V. Cherezov, Lipidic Cubic Phase Injector Facilitates Membrane Protein Serial Femtosecond Crystallography, Nature Communications 5, 1–6, (2014). http://www.nature.com/ncomms/2014/140214/ncomms4309/full/ncomms4309.html

  1. H. Liu, N.A. Zatsepin, and J.C.H. Spence, Ab-Initio Phasing Using Nanocrystal Shape Transforms with Incomplete Unit Cells, IUCrJ 1 (1), 19–27, (2014). http://journals.iucr.org/m/issues/2014/01/00/cw5001/cw5001.pdf

2013

  1. W. Liu, D. Wacker, C. Gati, G.W. Han, D. James, D. Wang, G. Nelson, U. Weierstall, V. Katritch, A. Barty, N.A. Zatsepin, D. Li, M. Messerschmidt, S. Boutet, G.J. Williams, J.E. Koglin, M.M. Seibert, C. Wang, S.T.A. Shah, S. Basu, R. Fromme, C. Kupitz, K.N. Rendek, I. Grotjohann, P. Fromme, R.A. Kirian, K.R. Beyerlein, T.A. White, H.N. Chapman, M. Caffrey, J.C.H. Spence, R.C. Stevens, and V. Cherezov, Serial Femtosecond Crystallography of G Protein-Coupled ReceptorsScience 342 (6165), 1521–1524, (2013). http://science.sciencemag.org/content/342/6165/1521

  1. T.A. White, A. Barty, F. Stellato, J.M. Holton, R.A. Kirian, N.A. Zatsepin, and H.N. Chapman, Crystallographic Data Processing for Free-Electron Laser Sources, Acta Crystallographica D69, 1231–1240, (2013). http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689526/

  1. L.C. Johansson, D. Arnlund, G. Katona, T.A. White, A. Barty, D.P. DePonte, R.L. Shoeman, C. Wickstrand, A. Sharma, G.J. Williams, A. Aquila, M.J. Bogan, C. Caleman, J. Davidsson, R.B. Doak, M. Frank, R. Fromme, L. Galli, I. Grotjohann, M.S. Hunter, S. Kassemeyer, R.A. Kirian, C. Kupitz, M. Liang, L. Lomb, E. Malmerberg, A.V. Martin, M. Messerschmidt, K. Nass, L. Redecke, M.M. Seibert, J.S.O. hamn, J. Steinbrener, F. Stellato, D. Wang, W.Y. Wahlgren, U. Weierstall, S. Westenhoff, N.A. Zatsepin, S.E.B. Boutet, J.C.H. Spence, I. Schlichting, H.N. Chapman, P. Fromme, and R. Neutze, Structure of a Photosynthetic Reaction Centredetermined by Serial Femtosecond Crystallography, Nature Communications 4, 1–7, (2013). http://www.nature.com/ncomms/2013/131219/ncomms3911/full/ncomms3911.html

  1. L. Redecke, K. Nass, D.P. DePonte, T.A. White, D. Rehders, A. Barty, F. Stellato, M. Liang, T.R.M. Barends, S. Boutet, G.J. Williams, M. Messerschmidt, M.M. Seibert, A.L. Aquila, D. Arnlund, S. Bajt, T. Barth, M.J. Bogan, C. Caleman, T.-C. Chao, R.B. Doak, H. Fleckenstein, M. Frank, R. Fromme, L. Galli, I. Grotjohann, M.S. Hunter, L.C. Johansson, S. Kassemeyer, G. Katona, R.A. Kirian, R. Koopmann, C. Kupitz, L. Lomb, A.V. Martin, S. Mogk, R. Neutze, R.L. Shoeman, J. Steinbrener, N. Timneanu, D. Wang, U. Weierstall, N.A. Zatsepin, J.C.H. Spence, P. Fromme, I. Schlichting, M. Duszenko, C. Betzel, and H.N. Chapman, Natively Inhibited Trypanosoma Brucei Cathepsin B Structure Determined by Using an X-Ray LaserScience 339 (6116), 20130311–20130311, (2013). http://science.sciencemag.org/content/339/6116/227.long

2012

  1. S. Boutet, L. Lomb, G.J. Williams, T.R.M. Barends, A.L. Aquila, R.B. Doak, U. Weierstall, D.P. DePonte, J. Steinbrener, R.L. Shoeman, M. Messerschmidt, A. Barty, T.A. White, S. Kassemeyer, R.A. Kirian, M.M. Seibert, P.A. Montanez, C. Kenney, R. Herbst, P. Hart, J. Pines, G. Haller, S.M. Gruner, H.T. Philipp, M.W. Tate, M. Hromalik, L.J. Koerner, N. van Bakel, J. Morse, W. Ghonsalves, D. Arnlund, M.J. Bogan, C. Caleman, R. Fromme, C.Y. Hampton, M.S. Hunter, L.C. Johansson, G. Katona, C. Kupitz, M. Liang, A.V. Martin, K. Nass, L. Redecke, F. Stellato, N. Timneanu, D. Wang, N.A. Zatsepin, D.W. Schafer, J. Defever, R. Neutze, P. Fromme, J.C.H. Spence, H.N. Chapman, and I. Schlichting, High-Resolution Protein Structure Determination by Serial Femtosecond CrystallographyScience 336 (6092), 362–364, (2012). http://science.sciencemag.org/content/337/6092/362

2010

  1. N.A. Zatsepin, R.A. Dilanian, A.Y. Nikulin, X. Gao, B.C. Muddle, V.N. Matveev, and O. Sakata, Real-Time in Situ Nanoclustering During Initial Stages of Artificial Aging of Al–Cu Alloys, Journal of Applied Physics 107 (2), 024303, [2010]. http://scitation.aip.org/content/aip/journal/jap/107/2/10.1063/1.3280014

2008

  1. N.A. Zatsepin, R.A. Dilanian, A.Y. Nikulin, B.M. Gable, B.C. Muddle, and O. Sakata, Toward in Situ X-Ray Diffraction Imaging at the Nanometer Scale, NanoScience+ Engineering, Proceedings of SPIE 7042, 70420F 1–10, [2008].

  1. A.Y. Nikulin, R.A. Dilanian, N.A. Zatsepin, and B.C. Muddle, Three-Dimensional X-Ray Diffraction Nanoscopy, NanoScience+ Engineering, Proceedings of SPIE 7042, 70420H 1–10, [2008].

  1. N.A. Zatsepin, R.A. Dilanian, A.Y. Nikulin, B.M. Gable, B.C. Muddle, and O. Sakata, Early Detection of Nanoparticle Growth From X-Ray Reciprocal Space Mapping, Applied Physics Letters 92 (3), 034101, [2008]. http://scitation.aip.org/content/aip/journal/apl/92/3/10.1063/1.2829606

2007

  1. A.Y. Nikulin, R.A. Dilanian, N.A. Zatsepin, B.M. Gable, B.C. Muddle, A.Y. Souvorov, Y. Nishino, and T. Ishikawa, 3-D X-Ray Diffraction Imaging with Nanoscale Resolution Using Incoherent Radiation, Nano Letters 7 (5), 1246–1250, [2007]. http://pubs.acs.org/doi/abs/10.1021/nl070131z

Courses

Fall 2018
Course Number Course Title
PHY 492 Honors Directed Study
Summer 2018
Course Number Course Title
PHY 792 Research
Summer 2017
Course Number Course Title
PHY 792 Research
Spring 2017
Course Number Course Title
PHY 792 Research

Presentations

Invited Talks

  1. High-resolution room-temperature serial microcrystallography at synchrotrons with a high viscosity medium injector and snapshot serial crystallography analysis. Seminar at NSLS II, Brookhaven National Lab. 2018.

  2. BioXFEL: using x-ray lasers to study the ultrasmall and ultrafast in biology. Conference for Undergraduate Women in Physics, Arizona State University, AZ, USA 2018
  3. Time-resolved serial femtosecond crystallography at XFELs. National Institute of Health, Frederick, MD, 2017
  4. Serial millisecond protein crystallography using synchrotron radiation: Opportunities and Challenges, Seminar, Synchrotron SOLEIL, August 2017, Paris, France
  5. Serial millisecond crystallography at the Advanced Photon Source, CHESS User Meeting workshop Advances in Serial Synchrotron Crystallography, 2017 June, Cornell University, NY, USA
  6. X-ray free-electron laser applications in biology, Asia Oceania Forum for Synchrotron Radiation School, 2017 Melbourne, Australia
  7. Between and beyond Bragg reflections: Macromolecular diffractive imaging from crystals & finite crystal phasing at XFELs, Understanding Biology Through Structure 2017, Santa Fe, NM, USA
  8. Serial femtosecond x-ray crystallography of carbon monoxide-bound Cytochrome c Oxidase. 4th Annual BioXFEL International Conference, January 2017, Las Vegas, USA.
  9. Serial femtosecond crystallography at LCLS: the first 5 years. 5th International Symposium on Diffraction Structural Biology, August 7, 2016, Oak Ridge National Laboratory, Tennessee, USA.
  10. Making the most out of XFELs. Gordon Research Conference on Diffraction Methods in Biology, Lewiston, ME, USA, 2016.
  11. Serial femtosecond crystallography with XFELs: Data Analysis and Research Highlights. SwissFEL Seminar, Paul Scherrer Institute, Switzerland, 2016.
  12. Highlights in Data Analysis Developments. BioXFEL NSF Site visit, Buffalo, NY, 2016.
  13. Serial femtosecond crystallography using XFELs. Physics Seminar, La Trobe University, Australia. 2015.
  14. Serial femtosecond crystallography using XFELs. Physics Seminar, Monash University, Australia. 2015.
  15. Association of BioXFEL Young Scientists (ABYS) workshops 2015. BioXFEL STC 2ndAnnual International Conference, Ponce, Puerto Rico, USA, 2015.
  16. Software Tools for the Analysis of Serial Crystallography Data. IUCr 2014 Workshop on Crystallography at XFEL Sources. Montr�al, Canada, 2014.
  17. Serial femtosecond protein nanocrystallography using a free electron laser. Dept. of Physics Colloquium, U. Wisconsin-Milwaukee, 2013.
  18. Serial femtosecond nanocrystallography data analysis. Workshop on Dynamic Structural Photocrystallography in Chemistry & Materials Science, University at Buffalo, SUNY, New York, USA. 2013.
  19. High-resolution diffraction from membrane protein nanocrystals using serial femtosecond crystallography. Gordon Research Conference on Diffraction Methods in Structural Biology, selected as speaker from poster session. Maine, USA, 2012.
  20. Development of a New In Situ X-ray Diffraction Technique for Characterising Embedded Nanoparticle Seminar at Paul Scherrer Institut, 2009.
  21. Advances in real time X-ray diffraction in-situ nanoscopy. X-ray Micro & Nanoprobes, Palinuro, Italy, June 2009.
  22. Toward in situ X-ray diffraction imaging at the nanometer scale. SPIE Optics and Photonics: NanoScience and Engineering, San Diego, CA, 2008.

 

Workshops

  1. Organized the Eu-XFEL Workshop at BioXFEL 5 Annual Conference, New Orleans, LA, 2018. 
  2. Organized and instructed at the 2016 ACA Serial Crystallography Data Analysis Workshop, an international computational workshop held at the American Crystallographic Association Annual Meeting. July 2016, Denver, CO, USA.
  3. Organized and instructed at Serial crystallography data analysis with Cheetah and CrystFEL: concepts and tutorials, a sold-out, international computational workshop at ACA Annual Meeting, July 2015 in Philadelphia, PA, USA.
  4. Organized and presented at the Conference for BioXFEL Students and Postdocs at the SSRL/LCLS Annual Users Meeting and Workshops, Palo Alto, USA, October 2014.
  5. Organized and instructed at the Two-day workshop on Bio-XFEL data analysis. Lawrence Berkeley National Lab, 21-22 August 2014.
  6. Ran workshop on Computer exercises: Introduction to serial femtosecond crystallography data analysis with CrystFEL. Workshop on Dynamic Structural Photocrystallography in Chemistry & Materials Science, University at Buffalo, SUNY, New York, USA, 2013.
  7. Instructed at Nanocrystal data analysis workshop, CFEL, Hamburg, 22nd April 2013.

 

Conference contributions

  • Co-chair of BioXFEL 6th Annual International Conference, to be held in San Diego, February 2019. https://www.bioxfel.org/events/details/1183
  • Chair of conference session New Measurement and Analysis Strategies at the BioXFEL 5th Annual International Conference, New Orleans, LA, USA, 2018.
  • Chair of conference session Advances in multi-crystal approaches and serial crystallography at the 2015 Annual Meeting of the American Crystallographic Association, 2015, Philadelphia, PA, USA.
  • Conference session Chair and presenter for Updates on Photosystem I and II at the 4th Imager Retreat, Koenigstein, Germany. 23-24 April 2013.

Honors/Awards

2012 Ultrafast X-ray Summer School (SLAC) poster prize
2006-2009 Australian Postgraduate Award
2008 SPIE Scholarship in Optical Science and Engineering
2005 J.L. William Honours scholarship, Monash University
2005 J.J. McNeil Prize for top Honours student in physics, Monash University 

Professional Associations

www.bioxfel.org

Member of American Crystallographic Association.

Service

Science outreach

2015: Guide for LCLS serial femtosecond crystallography data analysis.

2008: Intern at Catalyst, Australian Broadcasting Corporation: researched science news and developed publicly accessible stories from formal scientific publications.

2004 – 2007: Instructor at Siemens Science Week for year 10 students: led interactive sessions on the physics and mathematics of soap film and optimization at this annual event at Monash University, Australia.

2005: Presenter on “Totally Wild” (Network TEN, Australia): Short TV segment on the science of soap film and bubbles on a children’s weekly science show on national television,

Graduate Faculties / Mentoring History

Department of Physics Graduate Faculty

Work History

2011 - Current: Arizona State University.

2005 - 2010: Monash University, Australia.