Nadia Zatsepin

Research Assistant Professor
TEMPE Campus


Nadia Zatsepin is an assistant research professor in the Center for Biological Physics in the Department of Physics. Her research focuses on the application and development of data analysis tools for time resolved serial femtosecond crystallography, extension of serial crystallography to synchrotron sources, and novel phasing algorithms for XFEL biological data.

Zatsepin's graduate studies were on X-ray characterization of nanoparticles embedded in light metal alloys, at Monash University (Melbourne, Australia). She joined ASU in 2011 as a postdoc with Professor John Spence. 

Zatsepin's work is supported by the BioXFEL STC (NSF STC award number 1231306) and NSF BIO ABI award #1565180 “ABI Innovations: New Algorithms for biological X-ray free electron laser data”.


  • Ph.D. Physics, Monash University, Australia 2011
  • B.Sc. Sci Schol Prog., Monash University, Australia 2005

Research Interests

serial femtosecond crystallography, phasing, coherent diffractive imaging, macromolecular serial crystallography, biophysics, structural biology 





  1. C. Gati, D. Oberthuer, O.M. Yefanov, R.D. Bunker, F. Stellato, E. Chiu, S.-M. Yeh, A. Aquila, S. Basu, R. Bean, K.R. Beyerlein, S. Botha, S. Boutet, D.P. DePonte, R.B. Doak, R. Fromme, L. Galli, I. Grotjohann, D.R. James, C. Kupitz, L. Lomb, M.M. Messerschmidt, K. Nass, K. Rendek, R.L. Shoeman, D. Wang, U. Weierstall, T.A. White, G.J. Williams, N.A. Zatsepin, P.T. Fromme, J.C.H. Spence, K.N. Goldie, J.A. Jehle, P. Metcalf, A. Barty, and H.N. Chapman, Atomic Structure of Granulin Determined From Native Nanocrystalline Granulovirus Using an X-Ray Free-Electron Laser, Proceedings of the National Academy of Sciences 114 (9), 2247–2252, [2017].

  1. C. Kupitz, J.L. Olmos Jr., M. Holl, L. Tremblay, K. Pande, S. Pandey, D. Oberthür, M. Hunter, M. Liang, A. Aquila, J. Tenboer, G. Calvey, A. Katz, Y. Chen, M.O. Wiedorn, J. Knoska, A. Meents, V. Majriani, T. Norwood, I. Poudyal, T.D. Grant, M.D. Miller, W. Xu, A. Tolstikova, A. Morgan, M. Metz, J.M. Martin-Garcia, J.D. Zook, S. Roy-Chowdhury, J. Coe, N. Nagaratnam, D. Meza, R. Fromme, S. Basu, M. Frank, T.A. White, A. Barty, S. Bajt, O.M. Yefanov, H.N. Chapman, N.A. Zatsepin, G. Nelson, U. Weierstall, J.C.H. Spence, P. Schwander, L. Pollack, P.T. Fromme, A. Ourmazd, G.N. Phillips Jr, and M. Schmidt, Structural Enzymology Using X-Ray Free Electron Lasers, Structural Dynamics 4 (4), 044003, [2017].

  1. J.R. Stagno, Y. Liu, Y.R. Bhandari, C.E. Conrad, S. Panja, M. Swain, L. Fan, G. Nelson, C. Li, D.R. Wendel, T.A. White, J.D. Coe, M.O. Wiedorn, J. Knoska, D. Oberthuer, R.A. Tuckey, P. Yu, M. Dyba, S.G. Tarasov, U. Weierstall, T.D. Grant, C.D. Schwieters, J. Zhang, A.R. Ferré-D’Amaré, P. Fromme, D.E. Draper, M. Liang, M.S. Hunter, S. Boutet, K. Tan, X. Zuo, X. Ji, A. Barty, N.A. Zatsepin, H. N. Chapman, J.C.H. Spence, S. A. Woodson & Y.-X. Wang. Structures of riboswitch RNA reaction states by mix-and-inject XFEL serial crystallographyNature 541, 242-246, [2017]. doi:10.1038/nature20599


  1. T. A. White, A. Barty, W. Liu, A. Ishchenko, H. Zhang, C. Gati, N. A. Zatsepin, S. Basu, D. Oberthür, M. Metz, K. R. Beyerlein, C. H. Yoon, O. M. Yefanov, D. James, D. Wang, M. Messerschmidt, J. E. Koglin, S. Boutet, U. Weierstall, and V. Cherezov. Serial femtosecond crystallography datasets from G protein-coupled receptors, Scientific Data, 3 [2016].

  1. G. Nelson, R.A. Kirian, U. Weierstall, N.A. Zatsepin, T. Faragó, T. Baumbach, F. Wilde, F.B.P. Niesler, B. Zimmer, I. Ishigami, M. Hikita, S. Bajt, S.-R. Yeh, D.L. Rousseau, H.N. Chapman, J.C.H. Spence, and M. Heymann, Three-Dimensional-Printed Gas Dynamic Virtual Nozzles for X-Ray Laser Sample Delivery, Opt. Express 24 (11), 11515, [2016].

  1. K. Pande, C.D.M. Hutchison, G. Groenhof, A. Aquila, J.S. Robinson, J. Tenboer, S. Basu, S. Boutet, D.P. DePonte, M. Liang, T.A. White, N.A. Zatsepin, O. Yefanov, D. Morozov, D. Oberthuer, C. Gati, G. Subramanian, D. James, Y. Zhao, J. Koralek, J. Brayshaw, C. Kupitz, C. Conrad, S. Roy-Chowdhury, J.D. Coe, M. Metz, P.L. Xavier, T.D. Grant, J.E. Koglin, G. Ketawala, R. Fromme, V. Srajer, R. Henning, J.C.H. Spence, A. Ourmazd, P. Schwander, U. Weierstall, M. Frank, P. Fromme, A. Barty, H.N. Chapman, K. Moffat, J.J. van Thor, and M. Schmidt, Femtosecond Structural Dynamics Drives the Trans/Cis Isomerization in Photoactive Yellow ProteinScience 352 (6286), 725–729, [2016].


  1. D. Li, P.J. Stansfeld, M.S.P. Sansom, A. Keogh, L. Vogeley, N. Howe, J.A. Lyons, D. Aragao, P. Fromme, R. Fromme, S. Basu, I. Grotjohann, C. Kupitz, K. Rendek, U. Weierstall, N.A. Zatsepin, V. Cherezov, W. Liu, S. Bandaru, N.J. English, C. Gati, A. Barty, O. Yefanov, H.N. Chapman, K. Diederichs, M. Messerschmidt, S.E.B. Boutet, G.J. Williams, M.M. Seibert, and M. Caffrey, Ternary Structure Reveals Mechanism of a Membrane Diacylglycerol Kinase, Nature Communications 6, 1–12, [2015].

  1. B.G. Abdallah, N.A. Zatsepin, S. Roy-Chowdhury, J. Coe, C.E. Conrad, K. Dörner, R.G. Sierra, H.P. Stevenson, F. Camacho-Alanis, T.D. Grant, G. Nelson, D. James, G. Calero, R.M. Wachter, J.C.H. Spence, U. Weierstall, P. Fromme, and A. Ros, Microfluidic Sorting of Protein Nanocrystals by Size for X-Ray Free-Electron Laser Diffraction, Structural Dynamics 2 (4), 041719, [2015].

  1. R.M. Lawrence, C.E. Conrad, N.A. Zatsepin, T.D. Grant, H. Liu, D. James, G. Nelson, G. Subramanian, A. Aquila, M.S. Hunter, M. Liang, S. Boutet, J. Coe, J.C.H. Spence, U. Weierstall, W. Liu, P. Fromme, V. Cherezov, and B.G. Hogue, Serial Femtosecond X-Ray Diffraction of Enveloped Virus Microcrystals, Structural Dynamics 2 (4), 041720, [2015].

  1. C.E. Conrad, S. Basu, D. James, D. Wang, A. Schaffer, S. Roy-Chowdhury, N.A. Zatsepin, A. Aquila, J. Coe, C. Gati, M.S. Hunter, J.E. Koglin, C. Kupitz, G. Nelson, G. Subramanian, T.A. White, Y. Zhao, J. Zook, S. Boutet, V. Cherezov, J.C.H. Spence, R. Fromme, U. Weierstall, and P. Fromme, A Novel Inert Crystal Delivery Medium for Serial Femtosecond Crystallography, IUCrJ 2, 421–430, [2015].

  1. Y. Kang, X.E. Zhou, X. Gao, Y. He, W. Liu, A. Ishchenko, A. Barty, T.A. White, O. Yefanov, G.W. Han, Q. Xu, P.W. de Waal, J. Ke, M.H.E. Tan, C. Zhang, A. Moeller, G.M. West, B.D. Pascal, N. van Eps, L.N. Caro, S.A. Vishnivetskiy, R.J. Lee, K.M. Suino-Powell, X. Gu, K. Pal, J. Ma, X. Zhi, S. Boutet, G.J. Williams, M. Messerschmidt, C. Gati, N.A. Zatsepin, D. Wang, D. James, S. Basu, S. Roy-Chowdhury, C.E. Conrad, J. Coe, H. Liu, S. Lisova, C. Kupitz, I. Grotjohann, R. Fromme, Y. Jiang, M. Tan, H. Yang, J. Li, M. Wang, Z. Zheng, D. Li, N. Howe, Y. Zhao, J. Standfuss, K. Diederichs, Y. Dong, C.S. Potter, B. Carragher, M. Caffrey, H. Jiang, H.N. Chapman, J.C.H. Spence, P. Fromme, U. Weierstall, O.P. Ernst, V. Katritch, V.V. Gurevich, P.R. Griffin, W.L. Hubbell, R.C. Stevens, V. Cherezov, K. Melcher, and H.E. Xu, Crystal Structure of Rhodopsin Bound to Arrestin by Femtosecond X-Ray Laser, Nature 523 (7562), 561–567, [2015].

  1. H. Zhang, H. Unal, C. Gati, G.W. Han, W. Liu, N.A. Zatsepin, D. James, D. Wang, G. Nelson, U. Weierstall, M.R. Sawaya, Q. Xu, M. Messerschmidt, G.J. Williams, S. Boutet, O.M. Yefanov, T.A. White, C. Wang, A. Ishchenko, K.C. Tirupula, R. Desnoyer, J. Coe, C.E. Conrad, P. Fromme, R.C. Stevens, V. Katritch, S.S. Karnik, and V. Cherezov, Structure of the Angiotensin Receptor Revealed by Serial Femtosecond Crystallography, Cell, 161 (4), 833-844, [2015].

  1. A. Soragni, S. Yousefi, C. Stoeckle, A.B. Soriaga, M.R. Sawaya, E. Kozlowski, I. Schmid, S. Radonjic-Hoesli, S. Boutet, G.J. Williams, M. Messerschmidt, M.M. Seibert, D. Cascio, N.A. Zatsepin, M. Burghammer, C. Riekel, J.-P. Colletier, R. Riek, D.S. Eisenberg, and H.-U. Simon, Toxicity of Eosinophil MBP Is Repressed by Intracellular Crystallization and Promoted by Extracellular Aggregation, Molecular Cell 57 (6), 1011–1021, (2015).

  1. G. Fenalti, N.A. Zatsepin, C. Betti, P. Giguere, G.W. Han, A. Ishchenko, W. Liu, K. Guillemyn, H. Zhang, D. James, D. Wang, U. Weierstall, J.C.H. Spence, S. Boutet, M. Messerschmidt, G.J. Williams, C. Gati, O.M. Yefanov, T.A. White, D. Oberthuer, M. Metz, C.H. Yoon, A. Barty, H.N. Chapman, S. Basu, J. Coe, C.E. Conrad, R. Fromme, P. Fromme, D. Tourwé, P.W. Schiller, B.L. Roth, S. Ballet, V. Katritch, R.C. Stevens, and V. Cherezov, Structural Basis for Bifunctional Peptide Recognition at Human δ-Opioid Receptor, Nature Structural & Molecular Biology 22(3), 265–268, (2015).

  1. P. Nogly, D. James, D. Wang, T.A. White, N.A. Zatsepin, A. Shilova, G. Nelson, H. Liu, L.C. Johansson, M. Heymann, K. Jaeger, M. Metz, C. Wickstrand, W. Wu, P. Bath, P. Bernsten, D. Oberthuer, V. Panneels, V. Cherezov, H.N. Chapman, G. Schertler, R. Neutze, J.C.H. Spence, I. Moraes, M. Burghammer, J. Standfuss, and U. Weierstall, Lipidic Cubic Phase Serial Millisecond Crystallography Using Synchrotron Radiation, IUCrJ, 2, 168-176, (2015).


  1. M. Frank, D.B. Carlson, M.S. Hunter, G.J. Williams, M. Messerschmidt, N.A. Zatsepin, A. Barty, W.H. Benner, K. Chu, A.T. Graf, S.P. Hau-Riege, R.A. Kirian, C. Padeste, T. Pardini, B. Pedrini, B. Segelke, M.M. Seibert, J.C.H. Spence, C.-J. Tsai, S.M. Lane, X.-D. Li, G. Schertler, S. Boutet, M. Coleman, and J.E. Evans, Femtosecond X-Ray Diffraction From Two-Dimensional Protein Crystals, IUCrJ (2014) 1, 95–100, (2014).

  1. H.-H. Lee, I. Cherni, H. Yu, R. Fromme, J.D. Doran, I. Grotjohann, M. Mittman, S. Basu, A. Deb, K. Dörner, A. Aquila, A. Barty, S. Boutet, H.N. Chapman, R.B. Doak, M.S. Hunter, D. James, R.A. Kirian, C. Kupitz, R.M. Lawrence, H. Liu, K. Nass, I. Schlichting, K.E. Schmidt, M.M. Seibert, R.L. Shoeman, J.C.H. Spence, F. Stellato, U. Weierstall, G.J. Williams, C.H. Yoon, D. Wang, N.A. Zatsepin, B.G. Hogue, N. Matoba, P. Fromme, and T.S. Mor, Expression, Purification and Crystallization of CTB-MPR, a Candidate Mucosal Vaccine Component Against HIV-1, IUCrJ (2014) 1, 305–317, (2014).

  1. K.R. Beyerlein, C. Jooss, A. Barty, R. Bean, S. Boutet, S.S. Dhesi, R.B. Doak, M. Först, L. Galli, R.A. Kirian, J. Kozak, M. Lang, R. Mankowsky, M. Messerschmidt, J.C.H. Spence, D. Wang, U. Weierstall, T.A. White, G.J. Williams, O. Yefanov, N.A. Zatsepin, A. Cavalleri, and H.N. Chapman, Trace Phase Detection and Strain Characterization From Serial X-Ray Free-Electron Laser Crystallography of a Pr0.5Ca0.5MnO3 Powder, Powder Diffraction, 1–6, (2014).

  1. M.S. Hunter, B. Segelke, M. Messerschmidt, G.J. Williams, N.A. Zatsepin, A. Barty, W.H. Benner, D.B. Carlson, M. Coleman, A. Graf, S.P. Hau-Riege, T. Pardini, M.M. Seibert, J. Evans, S. Boutet, and M. Frank, Fixed-Target Protein Serial Microcrystallography with an X-Ray Free Electron Laser, Scientific Reports 4, (2014).

  1. D. Arnlund, L.C. Johansson, C. Wickstrand, A. Barty, G.J. Williams, E. Malmerberg, J. Davidsson, D. Milathianaki, D.P. DePonte, R.L. Shoeman, D. Wang, D. James, G. Katona, S. Westenhoff, T.A. White, A. Aquila, S. Bari, P. Berntsen, M. Bogan, T.B. van Driel, R.B. Doak, K.S. Kjær, M. Frank, R. Fromme, I. Grotjohann, R. Henning, M.S. Hunter, R.A. Kirian, I. Kosheleva, C. Kupitz, M. Liang, A.V. Martin, M.M. Nielsen, M. Messerschmidt, M.M. Seibert, J. Sjöhamn, F. Stellato, U. Weierstall, N.A. Zatsepin, J.C.H. Spence, P. Fromme, I. Schlichting, S. Boutet, G. Groenhof, H.N. Chapman, and R. Neutze, Visualizing a Protein Quake with Time-Resolved X-Ray Scattering at a Free-Electron Laser, Nature Methods 11 (9), 923–926, (2014).

  1. C. Kupitz, S. Basu, I. Grotjohann, R. Fromme, N.A. Zatsepin, K.N. Rendek, M.S. Hunter, R.L. Shoeman, T.A. White, D. Wang, D. James, J.-H. Yang, D.E. Cobb, B. Reeder, R.G. Sierra, H. Liu, A. Barty, A.L. Aquila, D. Deponte, R.A. Kirian, S. Bari, J.J. Bergkamp, K.R. Beyerlein, M.J. Bogan, C. Caleman, T.-C. Chao, C.E. Conrad, K.M. Davis, H. Fleckenstein, L. Galli, S.P. Hau-Riege, S. Kassemeyer, H. Laksmono, M. Liang, L. Lomb, S. Marchesini, A.V. Martin, M. Messerschmidt, D. Milathianaki, K. Nass, A. Ros, S. Roy-Chowdhury, K. Schmidt, M. Seibert, J. Steinbrener, F. Stellato, L. Yan, C. Yoon, T.A. Moore, A.L. Moore, Y. Pushkar, G.J. Williams, S. Boutet, R.B. Doak, U. Weierstall, M. Frank, H.N. Chapman, J.C.H. Spence, and P. Fromme, Serial Time-Resolved Crystallography of Photosystem II Using a Femtosecond X-Ray Laser, Nature 513 (7517), 261–265, (2014).

  1. J.C.H. Spence, N.A. Zatsepin, and C. Li, Coherent Convergent-Beam Time-Resolved X-Ray Diffraction, Philosophical Transactions of the Royal Society B: Biological Sciences 369 (1647), 20130325–20130325, (2014).

  1. B. Pedrini, C.-J. Tsai, G. Capitani, C. Padeste, M.S. Hunter, N.A. Zatsepin, A. Barty, W.H. Benner, S. Boutet, G.K. Feld, S.P. Hau-Riege, R.A. Kirian, C. Kupitz, M. Messerschmitt, J.I. Ogren, T. Pardini, B. Segelke, G.J. Williams, J.C.H. Spence, R. Abela, M. Coleman, J.E. Evans, G.F.X. Schertler, M. Frank, and X.-D. Li, 7 Å Resolution in Protein Two-Dimensional-Crystal X-Ray Diffraction at Linac Coherent Light Source, Philosophical Transactions of the Royal Society B: Biological Sciences 369 (1647), 20130500, (2014).

  1. J. Tenboer, S. Basu, N. Zatsepin, K. Pande, D. Milathianaki, M. Frank, M. Hunter, S. Boutet, G.J. Williams, J.E. Koglin, D. Oberthuer, M. Heymann, C. Kupitz, C. Conrad, J. Coe, S. Roy-Chowdhury, U. Weierstall, D. James, D. Wang, T. Grant, A. Barty, O. Yefanov, J. Scales, Cornelius Gati, C. Seuring, V. Srajer, R. Henning, P. Schwander, R. Fromme, A. Ourmazd, Keith Moffat, J.J. Van Thor, J.C.H. Spence, P. Fromme, Henry N Chapman, and M. Schmidt, Time-Resolved Serial Crystallography Captures High-Resolution Intermediates of Photoactive Yellow ProteinScience 346 (6214), 1242–1246, (2014).

  1. U. Weierstall, D. James, C. Wang, T.A. White, D. Wang, W. Liu, J.C.H. Spence, R.B. Doak, G. Nelson, P. Fromme, R. Fromme, I. Grotjohann, C. Kupitz, N.A. Zatsepin, H. Liu, S. Basu, D. Wacker, G.W. Han, V. Katritch, S.E.B. Boutet, M. Messerschmidt, G.J. Williams, J.E. Koglin, M.M. Seibert, M. Klinker, C. Gati, R.L. Shoeman, A. Barty, H.N. Chapman, R.A. Kirian, K.R. Beyerlein, R.C. Stevens, D. Li, S.T.A. Shah, N. Howe, M. Caffrey, and V. Cherezov, Lipidic Cubic Phase Injector Facilitates Membrane Protein Serial Femtosecond Crystallography, Nature Communications 5, 1–6, (2014).

  1. H. Liu, N.A. Zatsepin, and J.C.H. Spence, Ab-Initio Phasing Using Nanocrystal Shape Transforms with Incomplete Unit Cells, IUCrJ 1 (1), 19–27, (2014).


  1. W. Liu, D. Wacker, C. Gati, G.W. Han, D. James, D. Wang, G. Nelson, U. Weierstall, V. Katritch, A. Barty, N.A. Zatsepin, D. Li, M. Messerschmidt, S. Boutet, G.J. Williams, J.E. Koglin, M.M. Seibert, C. Wang, S.T.A. Shah, S. Basu, R. Fromme, C. Kupitz, K.N. Rendek, I. Grotjohann, P. Fromme, R.A. Kirian, K.R. Beyerlein, T.A. White, H.N. Chapman, M. Caffrey, J.C.H. Spence, R.C. Stevens, and V. Cherezov, Serial Femtosecond Crystallography of G Protein-Coupled ReceptorsScience 342 (6165), 1521–1524, (2013).

  1. T.A. White, A. Barty, F. Stellato, J.M. Holton, R.A. Kirian, N.A. Zatsepin, and H.N. Chapman, Crystallographic Data Processing for Free-Electron Laser Sources, Acta Crystallographica D69, 1231–1240, (2013).

  1. L.C. Johansson, D. Arnlund, G. Katona, T.A. White, A. Barty, D.P. DePonte, R.L. Shoeman, C. Wickstrand, A. Sharma, G.J. Williams, A. Aquila, M.J. Bogan, C. Caleman, J. Davidsson, R.B. Doak, M. Frank, R. Fromme, L. Galli, I. Grotjohann, M.S. Hunter, S. Kassemeyer, R.A. Kirian, C. Kupitz, M. Liang, L. Lomb, E. Malmerberg, A.V. Martin, M. Messerschmidt, K. Nass, L. Redecke, M.M. Seibert, J.S.O. hamn, J. Steinbrener, F. Stellato, D. Wang, W.Y. Wahlgren, U. Weierstall, S. Westenhoff, N.A. Zatsepin, S.E.B. Boutet, J.C.H. Spence, I. Schlichting, H.N. Chapman, P. Fromme, and R. Neutze, Structure of a Photosynthetic Reaction Centredetermined by Serial Femtosecond Crystallography, Nature Communications 4, 1–7, (2013).

  1. L. Redecke, K. Nass, D.P. DePonte, T.A. White, D. Rehders, A. Barty, F. Stellato, M. Liang, T.R.M. Barends, S. Boutet, G.J. Williams, M. Messerschmidt, M.M. Seibert, A.L. Aquila, D. Arnlund, S. Bajt, T. Barth, M.J. Bogan, C. Caleman, T.-C. Chao, R.B. Doak, H. Fleckenstein, M. Frank, R. Fromme, L. Galli, I. Grotjohann, M.S. Hunter, L.C. Johansson, S. Kassemeyer, G. Katona, R.A. Kirian, R. Koopmann, C. Kupitz, L. Lomb, A.V. Martin, S. Mogk, R. Neutze, R.L. Shoeman, J. Steinbrener, N. Timneanu, D. Wang, U. Weierstall, N.A. Zatsepin, J.C.H. Spence, P. Fromme, I. Schlichting, M. Duszenko, C. Betzel, and H.N. Chapman, Natively Inhibited Trypanosoma Brucei Cathepsin B Structure Determined by Using an X-Ray LaserScience 339 (6116), 20130311–20130311, (2013).


  1. S. Boutet, L. Lomb, G.J. Williams, T.R.M. Barends, A.L. Aquila, R.B. Doak, U. Weierstall, D.P. DePonte, J. Steinbrener, R.L. Shoeman, M. Messerschmidt, A. Barty, T.A. White, S. Kassemeyer, R.A. Kirian, M.M. Seibert, P.A. Montanez, C. Kenney, R. Herbst, P. Hart, J. Pines, G. Haller, S.M. Gruner, H.T. Philipp, M.W. Tate, M. Hromalik, L.J. Koerner, N. van Bakel, J. Morse, W. Ghonsalves, D. Arnlund, M.J. Bogan, C. Caleman, R. Fromme, C.Y. Hampton, M.S. Hunter, L.C. Johansson, G. Katona, C. Kupitz, M. Liang, A.V. Martin, K. Nass, L. Redecke, F. Stellato, N. Timneanu, D. Wang, N.A. Zatsepin, D.W. Schafer, J. Defever, R. Neutze, P. Fromme, J.C.H. Spence, H.N. Chapman, and I. Schlichting, High-Resolution Protein Structure Determination by Serial Femtosecond CrystallographyScience 336 (6092), 362–364, (2012).


  1. N.A. Zatsepin, R.A. Dilanian, A.Y. Nikulin, X. Gao, B.C. Muddle, V.N. Matveev, and O. Sakata, Real-Time in Situ Nanoclustering During Initial Stages of Artificial Aging of Al–Cu Alloys, Journal of Applied Physics 107 (2), 024303, [2010].


  1. N.A. Zatsepin, R.A. Dilanian, A.Y. Nikulin, B.M. Gable, B.C. Muddle, and O. Sakata, Toward in Situ X-Ray Diffraction Imaging at the Nanometer Scale, NanoScience+ Engineering, Proceedings of SPIE 7042, 70420F 1–10, [2008].

  1. A.Y. Nikulin, R.A. Dilanian, N.A. Zatsepin, and B.C. Muddle, Three-Dimensional X-Ray Diffraction Nanoscopy, NanoScience+ Engineering, Proceedings of SPIE 7042, 70420H 1–10, [2008].

  1. N.A. Zatsepin, R.A. Dilanian, A.Y. Nikulin, B.M. Gable, B.C. Muddle, and O. Sakata, Early Detection of Nanoparticle Growth From X-Ray Reciprocal Space Mapping, Applied Physics Letters 92 (3), 034101, [2008].


  1. A.Y. Nikulin, R.A. Dilanian, N.A. Zatsepin, B.M. Gable, B.C. Muddle, A.Y. Souvorov, Y. Nishino, and T. Ishikawa, 3-D X-Ray Diffraction Imaging with Nanoscale Resolution Using Incoherent Radiation, Nano Letters 7 (5), 1246–1250, [2007].


Summer 2017
Course Number Course Title
PHY 792 Research
Spring 2017
Course Number Course Title
PHY 792 Research


Invited talks

  1. Serial femtosecond x-ray crystallography of carbon monoxide-bound Cytochrome c Oxidase, 4th Annual BioXFEL International Conference, January 2017, Las Vegas, NV, USA.
  2. Serial femtosecond crystallography at LCLS: the first 5 years, 5th International Symposium on Diffraction Structural Biology, August 7, 2016, Oak Ridge National Laboratory, Oak Ridge, TN, USA.
  3. Making the most out of XFELs. Gordon Research Conference on Diffraction Methods in Biology, Lewiston, ME, USA, July 2016.
  4. Serial femtosecond crystallography with XFELs: Data Analysis and Research Highlights, SwissFEL Seminar, Paul Scherrer Institute, Switzerland, March 2016.
  5. Serial femtosecond crystallography data analysis workshops, BioXFEL External Advisors Meeting, Tempe, AZ, USA, 2015.
  6. Serial femtosecond crystallography using X-ray free electron lasers, La Trobe University, Australia. March 2015.
  7. Serial femtosecond crystallography using X-ray free electron lasers, Monash University, Australia. March 2015.
  8. Association of BioXFEL Young Scientists (ABYS) workshops 2015, BioXFEL STC 2nd Annual International Conference, Ponce, Puerto Rico, USA, January 2015.
  9. Software Tools for the Analysis of Serial Crystallography Data, IUCr 2014 Workshop on Crystallography at XFEL Sources. Montr�al, Canada, August 2014.
  10. Serial femtosecond protein nanocrystallography using a free electron laser, Dept. of Physics Colloquium, U. Wisconsin-Milwaukee, June 2013.
  11. Serial femtosecond nanocrystallography data analysis, Workshop on Dynamic Structural Photocrystallography in Chemistry & Materials Science, University at Buffalo, SUNY, New York, USA. 2013.
  12. High-resolution diffraction from membrane protein nanocrystals using serial femtosecond crystallography, Gordon Research Conference on Diffraction Methods in Structural Biology, invited poster talk. Maine, USA, 2012.
  13. Development of a New In Situ X-ray Diffraction Technique for Characterising Embedded Nanoparticles, Seminar at Paul Scherrer Institut, 2009.
  14. Advances in real time X-ray diffraction in-situ nanoscopy, X-ray Micro & Nanoprobes, Palinuro, Italy, June 2009.
  15. Toward in situ X-ray diffraction imaging at the nanometer scale, SPIE Optics and Photonics: NanoScience and Engineering, San Diego, CA, August 2008.



  1. Organizing and instructing at the 2018 ACA Serial Crystallography Data Analysis Workshop, an international computational workshop to be held at the BioXFEL 5th International Conference.
  2. Organizing and instructing at the 2016 ACA Serial Crystallography Data Analysis Workshop, an international computational workshop held at the American Crystallographic Association Annual Meeting. July 2016.
  3. Organized and instructed at Serial crystallography data analysis with Cheetah and CrystFEL: concepts and tutorials, a sold-out, international computational workshop at ACA Annual Meeting, July 2015 in Philadelphia, PA, USA.
  4. Co-organized and presented at the Conference for BioXFEL Students and Postdocs at the SSRL/LCLS Annual Users Meeting and Workshops, Palo Alto, USA, October 2014.
  5. Organized and instructed at the Two-day workshop on Bio-XFEL data analysis, Lawrence Berkeley National Lab, 21-22 August 2014.
  6. Led workshop on Computer exercises: Introduction to serial femtosecond crystallography data analysis with CrystFEL, at the Workshop on Dynamic Structural Photocrystallography in Chemistry & Materials Science, University at Buffalo, SUNY, New York, USA, 2013.
  7. Instructed at Nanocrystal data analysis workshop, CFEL, Hamburg, 22nd April 2013.




2012 Ultrafast X-ray Summer School (SLAC) poster prize
2006-2009 Australian Postgraduate Award
2008 SPIE Scholarship in Optical Science and Engineering
2005 J.L. William Honours scholarship, Monash University
2005 J.J. McNeil Prize for top Honours student in physics, Monash University 

Professional Associations

<p> Member of American Crystallographic Association.</p>


Science outreach

2015: Guide for LCLS serial femtosecond crystallography data analysis.

2008: Intern at Catalyst, Australian Broadcasting Corporation: researched science news and developed publicly accessible stories from formal scientific publications.

2004 – 2007: Instructor at Siemens Science Week for year 10 students: led interactive sessions on the physics and mathematics of soap film and optimization at this annual event at Monash University, Australia.

2005: Presenter on “Totally Wild” (Network TEN, Australia): Short TV segment on the science of soap film and bubbles on a children’s weekly science show on national television,

Work History

<p>2011 - Current: Arizona State University. 2005 - 2010: Monash University, Australia.</p>