Unravelling physical principles of the second secret of life

Submitted by sozkan on August 15, 2018 - 4:53pm

Allostery is a process of remote regulation of functional activity by which biological macromolecules (mostly proteins) transmit the effect of binding at one site to a distal functional site. Allostery has even been referred to as the ‘second secret of life’, and has remained as central focus in biophysics. A quantitative description of allostery is fundamental to understand most processes beyond the molecular level, such as cellular signaling and disease. Thus, it is the critical phenomenon to bridge different length scales in biology.

Unravelling physical principles of the second secret of life

Submitted by sozkan on August 15, 2018 - 4:52pm

Allostery is a process of remote regulation of functional activity by which biological macromolecules (mostly proteins) transmit the effect of binding at one site to a distal functional site. Allostery has even been referred to as the ‘second secret of life’, and has remained as central focus in biophysics. A quantitative description of allostery is fundamental to understand most processes beyond the molecular level, such as cellular signaling and disease. Thus, it is the critical phenomenon to bridge different length scales in biology.

Cancer cell mechanics in 3D environments

Submitted by rros1 on August 15, 2018 - 4:52pm

Cancer development is associated with changes in the mechanical properties of cells as well as the extracellular matrix. Few facts are known about the interplay of cells and the extracellular matrix (ECM) on the molecular level with respect to the transformation from a normal to a malignant cell. Atomic force microscopy (AFM) based nanoindentation can be used to quantify local mechanical properties of living cells.
In this rotation project, the student will work on the mechanical characterization of cells embedded in 3D matrices.

Pages